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It was the largest university in the South before the Civil War and even though the school suffered a brief decline in the reconstruction era, North Carolina bounced back before the end of the 19th Century to reclaim its place as one of the nation's premier public institutions

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Rather than emphasizing the biological importance of this increase in TPM, PM's researchers normalized the results by TPM and discussed whether the additives increased the amounts of each toxin in the smoke per unit TPM produced compared to the control cigarettes