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It has been described that smokers who develop COPD, apart from consuming a higher number of cigarettes, have a particular inhalation pattern: deeper inhalations and greater volume of smoke, allowing for a higher number of oxidizing agents that eventually could result in the development of COPD 4, 5

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Other common nicotine withdrawal symptoms include nicotine cravings, depression, restlessness, irritability, headaches, trouble concentrating, body or mental fatigue, increased appetite, and insomnia