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Long-term heavy alcohol use in individuals taking sertraline also produces alcohol use disorder-related complications including hepatic injury, which further impairs CYP2C19 sertraline metabolism, and alcohol-related cognitive impairment that amplifies the cognitive symptoms of depression

and (B) any foreign materials that are used in the production of the materials described in subdivision (e)(i)(A) or (e)(ii)(A), as the case may be

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