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Under the agencys current premarket review compliance policy, which it has recently indicated it may be reconsidering for certain types of e-cigarettes, 5 manufacturers of deemed noncombustible tobacco products such as ENDS that were on the market when the Deeming Rule went into effect have until August 8, 2022 to submit PMTAs, and can remain on the market through that date and pending FDA review

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Previous research has also identified a gap in knowledge on the specific health consequences of tobacco use 11,13