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Combining this with mortality data from the Global Burden of Disease (GBD) study allows estimation of life expectancy differences even in the absence of direct longitudinal data

[7] While the research base on e-cigarettes is still emerging, a number of studies have found that the flavoring used in e-cigarettes and e-liquids have been linked to serious health issues, including toxic effects on lung cells, including popcorn lung, as well as inflammation effects and negative effects on the immune system

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Additionally, centrilobular emphysema is related to smoking habits, and panlobular emphysema is associated with low body mass index (BMI)