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A key component of this process is the generation of reactive oxygen species (ROS), which plays a critical role in inflammatory diseases, including those of the gastrointestinal (GI) tract

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The project began as a single short starring Roberto Benigni and Steven Wright created back in 1986 for "Saturday Night Live." Subsequent segments were made in 1989 and 1993 (the latter winning the Short Film Palme d'Or at Cannes) and eventually, Jarmusch had enough sketches to qualify as a feature film, his ninth to date