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Proc Am Thorac Soc 3:503510 Chillappagari S, Preuss J, Licht S, Muller C, Mahavadi P, Sarode G, Vogelmeier C, Guenther A, Nahrlich L, Rubin BK, Henke MO (2015) Altered protease and antiprotease balance during a COPD exacerbation contributes to mucus obstruction

If its repeatedly exposed to the chemicals from tobacco smoke, the cells in the lining can mutate and become cancerous

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