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In the presence of the LC3 complex, the process of autophagy (self-eating) involves the engulfment of damaged mitochondria by autophagosomes, leading to the subsequent fusion of these vesicles with lysosomes for degradation (Ng et al., 2021) (Figure 4)

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Further evaluated mucocutaneous features included molluscoid pseudotumors, easy bruising, subcutaneous spheroids, inguinal, umbilical, and incisional hernia, keloid formation, gingival inflammation/recession, livedo reticularis, keratosis pilaris/hyperkeratosis of extensor surfaces, xerosis, striae distensae/rubrae, resistance to local anesthetic drugs, acquired cutis laxa/premature skin aging, piezogenic papules of the heels, abnormalities of the uvula, absent/short lingual frenulum, and light blue sclerae