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Neurobiological factors provide the strongest explanation for the link between smoking and schizophrenia, Lyons writes, because a direct neurochemical interaction can be demonstrated. Of particular interest is the interaction between nicotine and dopamine in the nucleus accumbens and prefrontal cortex

A review by the Los Angeles Times of more than 3,000 pages of internal Juul records, obtained by the Food and Drug Administration and released to a researcher through the Freedom of Information Act, found that the concept behind the formula that makes Juul so palatable and addictive dates back more than four decades to Reynolds laboratories

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