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importantly, cumulative exposure (measured in pack-years) was strongly associated with fibrosis severity, with each additional pack-year tripling the likelihood of advanced fibrosis (adjusted OR per pack-year: 3.2

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Yet, in the Peruvian Amazon, the geographical region believed to be tobacco's historical birthplace, this plant is associated with a strikingly different usage and repute: Tobacco (especially Nicotiana rustica L.) in this area is described as a potent medicinal plant, used topically or via ingestion to treat a variety of health conditions

[39] Rockwell attended a diplomatic party in Reykjavk where he met Thora Hallgrimsson, the niece of Iceland's ambassador to the United States