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Several factors explain why youll feel effects more intensely during initial exposure: Tolerance absence : Your nicotinic receptors havent desensitized yet, amplifying every sensation Rapid onset kinetics : Peak blood levels create stronger responses in untolerant bodies Genetic sensitivity : Variations in CHRNA10 genes can intensify dizziness and rush Individual variability : Hydration, metabolism, and blood sugar influence your response Brain development : Adolescent brains show heightened sensitivity, accelerating dependence risk The intensity of this first-time buzz is also why nicotine is considered highly addictive, as users often chase that initial powerful sensation that becomes harder to replicate over time

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- Sterling I needed to stop smoking because of my health and for my grandchildren who did not like the smell of the nicotine

10.7150/ijbs.75402 23 CaiM.LiJ.LinS.ChenX.HuangJ.JiangX.et al (2015)