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On September 9, 2021, the FDA finally faced a court-ordered deadline to review millions of premarket applications (known as PMTAs) from e-cigarette manufacturers to determine whether the products are appropriate for the protection of public health. The agency denied the applications of nearly a million flavored products, but more than 9 months after the FDAs deadline, it has yet to act on many of the most popular products with young people

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People misusing the substance often take very high doses of it reportedly up to 7500mg dose as compared to a standard dose of 25mg to 50 mg used to treat depression