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The industry insisted it couldnt make a fire-safe cigarette that would still appeal to smokers and instead promoted flame retardant furniture shifting attention to the couches and chairs that were going up in flames

Acetaldehyde was shown to alter cellular respiration in cultured microvascular endothelial hBMVEC cells, which mainly comprise the bloodbrain-barrier, thereby suggesting negative effects on bloodbrain-barrier integrity (121).Further, in cultured primary cortical neurons, acetaldehyde impaired mitochondrial respiration via NOX -mediated activation (122), and in brain mitochondria in vitro , acrolein inhibited mitochondrial respiration via complex I (123)

It affects about 4.5 million people a year in the United States